2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W650803
    Nemazoline 130759-56-7 98%
    Nemazoline (A-57219) is selective α-adrenergic agent with α1-agonist/α2-antagonist activity, which is used as a nasal decongestant. Nemazoline produces decongestion by α1-mediated contraction of capacitance vessels, but not compromises blood flow by virtue of α2-antagonism. Nemazoline also blocks endogenous noradrenaline-mediated α 2-constriction of the resistance vessels.
    Nemazoline
  • HY-W653969
    Arotinolol-d5 hydrochloride 2514848-16-7 98%
    Arotinolol-d5 (hydrochloride) is deuterium labeled Arotinolol. Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases.
    Arotinolol-d5 hydrochloride
  • HY-W674245
    10-Hydroxyhexadecanoic acid 23048-75-1 98%
    10-Hydroxyhexadecanoic acid is a hydroxy fatty acid found in Camembert cheese. 10-Hydroxyhexadecanoic acid can promote cholesterol efflux from ABCA1 and ABCG1, preventing the accumulation of excess cholesterol in cells. 10-Hydroxyhexadecanoic acid can be used in anti-atherosclerosis research.
    10-Hydroxyhexadecanoic acid
  • HY-W686186
    Prasugrel hydroxy thiolactone 947502-66-1 98%
    Prasugrel hydroxy thiolactone (compound M18) is a metabolite of Prasugrel (HY-15284). Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits Adenosine 5'-diphosphate (ADP, HY-W010918)-induced platelet aggregation.
    Prasugrel hydroxy thiolactone
  • HY-W699829
    (3R,5R)-Rosuvastatin Lactone-d6 98%
    (3R,5R)-Rosuvastatin Lactone-d6 is the deuterium labeled (3R,5R)-Rosuvastatin Lactone (HY-135406). (3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.
    (3R,5R)-Rosuvastatin Lactone-d6
  • HY-W701743
    3,4-Dihydroxyamphetamine hydrochloride 828-06-8 98%
    3,4-Dihydroxyamphetamine (α-Methyldopamine) (hydrochloride) is a secondary metabolite of 3,4-Methylenedioxymethamphetamine (MDMA). 3, 4-dihydroxyamphetamine (hydrochloride) is cytotoxic to rat hepatocytes. 3, 4-dihydroxyamphetamine (hydrochloride) is also used in the study of high blood pressure.
    3,4-Dihydroxyamphetamine hydrochloride
  • HY-W704079
    1-Stearoyl-sn-glycerol 22610-61-3 98.66%
    1-Stearoyl-sn-glycerol is (MG(18:0/0:0/0:0); L-(+)-1-Monostearin; 1-Octadecanoyl-sn-glycerol) is a monoglyceride and also a metabolite found in plasma, which can be used in metabolomic analysis of plasma for coronary artery lesions (CAL).
    1-Stearoyl-sn-glycerol
  • HY-W705434
    Dabigatran etexilate-d11 2469006-94-6 98%
    Dabigatran etexilate-d11 (BIBR 1048-d11) is the deuterium labeled Dabigatran etexilate (HY-10274). Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation.
    Dabigatran etexilate-d11
  • HY-W705539
    DL-Phenylephrine-d3 hydrochloride 2714485-34-2 98%
    DL-Phenylephrine-d3 hydrochloride ((±)-Phenylephrine-d3 hydrochloride) is the deuterium labeled DL-Phenylephrine hydrochloride (HY-W014726). DL-Phenylephrine ((±)-Phenylephrine) hydrochloride is a selective agonist of the alpha1-adrenergic receptor, exhibiting potent vasoconstrictive activity.
    DL-Phenylephrine-d3 hydrochloride
  • HY-W707407
    Bisoprolol-d7 1310012-16-8 98%
    Bisoprolol-d7 is deuterium labeled Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.
    Bisoprolol-d7
  • HY-W707554
    Ticlopidine hydrochloride-d6 2985259-58-1 98%
    Ticlopidine hydrochloride-d6 is the deuterium labeled Ticlopidine hydrochloride (HY-B0153A). 0
    Ticlopidine hydrochloride-d6
  • HY-W707656
    Aspirin-d7 98%
    Aspirin-d7 is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.
    Aspirin-d7
  • HY-W710337
    Colterol hydrochloride-d9 2714484-83-8 98%
    Colterol hydrochloride-d9 is the deuterium labeled Colterol hydrochloride (HY-128510A). Colterol hydrochloride is the hydrochloride salt form of Colterol (HY-128510). Colterol hydrochloride is the agonist for adrenergic receptor, and exhibits good affinity to β1-adrenoreceptor (heart) and β2-adrenoreceptor (lung) with IC50 of 645 nM and 147 nM. Colterol hydrochloride exhibits potential as a bronchodilator.
    Colterol hydrochloride-d9
  • HY-W710827
    N,N'-Methylenebisacrylamide-d6 98%
    N,N'-Methylenebisacrylamide-d6 is the deuterium labeled N,N'-Methylenebisacrylamide (HY-D0848). N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel.
    N,N'-Methylenebisacrylamide-d6
  • HY-W710915
    Aprindine hydrochloride-d10 98%
    Aprindine hydrochloride-d10 is the deuterium labeled Aprindine hydrochloride (HY-A0236A). Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.
    Aprindine hydrochloride-d10
  • HY-W714710
    Teopranitol 81792-35-0 98%
    Teopranitol (KC-046), a coronary vasodilator with a rather selective venous dilatation, is used for the study of the acute myocardial ischemia.
    Teopranitol
  • HY-W717329
    EC33 232261-88-0 98%
    EC33 is a selective aminopeptidase A (APA) inhibitor. EC33 blocks the pressor response of exogenous Ang II. EC33 does not cross the blood-brain barrier. EC33 has the potential for salt-dependent model of hypertension research.
    EC33
  • HY-W720736
    Tinazoline 62882-99-9 98%
    Tinazoline, imidazole derivative, is a vasoconstrictor. Tinazoline can as nasal decongestant for the research of common cold.
    Tinazoline
  • HY-W722221
    Colterol acetate 10255-14-8 98%
    Colterol acetate is a selective inhibitor of β-adrenergic receptors. Colterol acetate can relax tracheal smooth muscle (primarily acting on β2 receptors), reduce subspastic contractions of tricholoma (acting on β2), and increase contractility of left ventricular papillary muscles (acting on β1).
    Colterol acetate
  • HY-W728451
    URB694 904672-77-1 98%
    URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH.
    URB694
Cat. No. Product Name / Synonyms Application Reactivity